Selected Birth Defects in California

Rates per 1000 births

 

Birth Defect

Rate

95% Confidence Interval

Frequency

All chromosomes 1.96 1.80-2.12 1 in 511
Down syndrome 1.19 1.07-1.32 1 in 841
Gastrochisis 0.41 0.34-0.49 1 in 2422
Heart defects 3.28 3.07-3.50 1 in 305
Hypospadias (2nd & 3rd degree) 0.26 0.20-0.32 1 in 3882
Lower limbs 0.14 0.10-0.20 1 in 6911
Upper limbs 0.36 0.29-0.43 1 in 2806
Neural tube defects 0.62 0.53-0.72 1 in 1619
Anencephaly 0.20 0.15-0.26 1 in 4971
Spina bifida 0.43 0.36-0.51 1 in 2323
Omphalocele 0.14 0.10-0.20 1 in 6911
Oral clefts 1.67 1.52-1.82 1 in 600
Cleft lip w/wo cleft palate 1.11 0.99-1.24 1 in 900
Cleft palate alone 0.59 0.50-0.69 1 in 1696

Source: California Birth Defects Monitoring Program registry data.  Cases are actively ascertained from medical record review in hospitals, genetics centers, and chromosome laboratories.  Diagnoses to age 1 are included.

To minimize the random variation inherent in small numbers, we report 5-year averages from 8 counties that are a representative sample of California's birth population.   Rates from these counties are similar to those throughout the State.

 

Overall Rates

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