Gene-Environment Interaction References:

2006

Zhu H, Yang W, Lu W, Zhang J, Shaw GM, et al. A known functional polymorphism (Ile120Val) of the human PCMT1 gene and risk of spina bifida. Mol.Genet.Metab 2006;87:66-70.
Ref ID: 290

2005

Graham JM, Jr., Shaw GM. Gene-environment interactions in rare diseases that include common birth defects. Birth Defects Res.A Clin.Mol.Teratol. 2005;73:865-7.
Ref ID: 288

Shaw GM , Iovannisci DM, Yang W, Finnell RH, Carmichael SL, Cheng S, Lammer EJ. Endothelial nitric oxide synthase (NOS3) genetic variants, maternal smoking, vitamin use, and risk of human orofacial clefts. Am J Epidemiol 2005;162:1207-14.
Ref ID: 287

Lu W, Volcik K, Zhu H, Wen S, Shaw GM, Lammer EJ, Finnell RH. Genetic variation in the proto-oncogene SKI and risk for orofacial clefting. Mol.Genet.Metab 2005;86:412-6.
Ref ID: 286

Lammer EJ, Shaw GM, Iovannisci DM, Finnell RH. Maternal smoking, genetic variation of glutathione s-transferases, and risk for orofacial clefts. Epidemiology 2005;16:698-701.
Ref ID: 284

Zhu H, Lu W, Laurent C, Shaw GM, Lammer EJ, Finnell RH. Genes encoding catalytic subunits of protein kinase a and risk of spina bifida. Birth Defects Res.A Clin.Mol.Teratol. 2005;73:591-6.
Ref ID: 282

Shaw GM, Iovannisci DM, Yang W, Finnell RH, Carmichael SL, Cheng S, Lammer EJ. Risks of human conotruncal heart defects associated with 32 single nucleotide polymorphisms of selected cardiovascular disease-related genes. Am J Med Genet A. 2005;138(1):21-26.
Ref ID: 281

Olshan AF, Shaw GM, Millikan RC, Laurent C, Finnell RH. Polymorphisms in DNA repair genes as risk factors for spina bifida and orofacial clefts. Am J Med Genet A. 2005;135(3):268-273.
Ref ID: 275

2004

Lammer EJ, Shaw GM, Iovannisci DM, Finnell RH. Periconceptional multivitamin intake during early pregnancy, genetic variation of acetyl-N-transferase 1 (NAT1), and risk for orofacial clefts. Birth Defects Res A Clin Mol Teratol. 2004;70(11):846-852.
Ref ID: 272

Finnell RH, Shaw GM, Lammer EJ et al. Gene-nutrient interactions: importance of folates and retinoids during early embryogenesis. Toxicol Appl Pharmacol. 2004;198(2):75-85.
Ref ID: 270

Volcik KA, Zhu H, Finnell RH, Shaw GM, Canfield M, Lammer EJ. Evaluation of the jumonji gene and risk for spina bifida and congenital heart defects. Am J Med Genet 2004; 126A(2):215-217.
Ref ID: 265

Volcik KA, Zhu H, Finnell RH, Shaw GM, Canfield M, Lammer EJ. Evaluation of the Cited2 gene and risk for spina bifida and congenital heart defects. Am J Med Genet 2004; 126A(3):324-325.
Ref ID: 264

Lammer EJ, Shaw GM, Iovannisci DM, Van Waes J, Finnell RH. Maternal smoking and the risk of orofacial clefts: Susceptibility with NAT1 and NAT2 polymorphisms. Epidemiology 2004; 15(2):150-156.
Ref ID: 263

Zhu H, Wicker NJ, Volcik K, Zhang J, Shaw GM, Lammer EJ et al. Promoter haplotype combinations for the human PDGFRA gene are associated with risk of neural tube defects. Mol Genet Metab 2004; 81(2):127-132.
Ref ID: 260

2003

Volcik KA, Shaw GM , Zhu H, Lammer EJ, Laurent C , Finnell RH. Associations between polymorphisms within the thymidylate synthase gene and spina bifida Birth Defects Res Part A Clin Mol Teratol 2003; 67(11):924-928.
Ref ID: 259

Shaw GM , Zhu H, Lammer EJ, Yang W , Finnell RH. Genetic variation of infant reduced folate carrier (A80G) and risk of orofacial and conotruncal heart defects. Am J Epidemiol 2003; 158(8):747-752.
Ref ID: 253

Volcik KA, Shaw GM, Lammer EJ, Zhu H, Finnell RH. Evaluation of infant methylenetetrahydrofolate reductase genotype, maternal vitamin use, and risk of high versus low level spina bifida defects. Birth Defects Research Part A: Clinical & Molecular Teratology 2003; 67(3):154-157.
Ref ID: 248

Volcik KA, Shaw GM, Zhu H, Lammer EJ, Finnell RH. Risk factors for neural tube defects: associations between uncoupling protein 2 polymorphisms and spina bifida.Birth Defects Research Part A: Clinical & Molecular Teratology 2003; 67(3):158-161.
Ref ID: 246

Zhu H, Wicker NJ, Shaw GM, Lammer EJ, Hendricks K, Suarez L et al. Homocysteine remethylation enzyme polymorphisms and increased risks for neural tube defects. Molecular Genetics & Metabolism 2003; 78(3):216-221.
Ref ID: 240

Zhu H, Junker WM, Finnell RH, Brown S, Shaw GM, Lammer EJ et al. Lack of association between ZIC2 and ZIC3 genes and the risk of neural tube defects (NTDs) in hispanic populations.American Journal of Medical Genetics 2003; 116A(4):414-415.
Ref ID: 239

Zhu H, Barber R, Shaw GM, Lammer EJ, Finnell RH. Is Sonic hedgehog (SHH) a candidate gene for spina bifida? A pilot study. American Journal of Medical Genetics 2003; 117A(1):87-88.
Ref ID: 238

Shaw GM , Nelson V, Iovannisci DM, Finnell RH, Lammer EJ. Maternal occupational chemical exposures and biotransformation genotypes as risk factors for selected congenital anomalies. American Journal of Epidemiology 2003; 157(6):475-484.
Ref ID: 237

2002

Volcik KA, Zhu H, Shaw GM, Lammer EJ, Finnell RH. Apolipoprotein E and apolipoprotein B genotypes and risk for spina bifida.Teratology 2002; 66(5):257-259.
Ref ID: 232

Rasmussen SA, Lammer EJ, Shaw GM, Finnell RH, McGehee RE, Jr., Gallagher M et al. Integration of DNA sample collection into a multi-site birth defects case-control study.Teratology 2002; 66(4):177-184.
Ref ID: 231

Finnell RH, Shaw GM, Lammer EJ, Volcik KA. Does prenatal screening for 5,10-methylenetetrahydrofolate reductase (MTHFR) mutations in high-risk neural tube defect pregnancies make sense? Genetic Testing 2002; 6(1):47-52.
Ref ID: 227

Shaw GM , Lammer EJ, Zhu H, Baker MW, Neri E, Finnell RH. Maternal periconceptional vitamin use, genetic variation of infant reduced folate carrier (A80G), and risk of spina bifida.American Journal of Medical Genetics 2002; 108(1):1-6.
Ref ID: 226

Croen LA, Shaw GM, Barber RC, Baker MM, Finnell RH, Lammer EJ. Apolipoprotein B and apolipoprotein E genotypes and sporadic holoprosencephaly. AmericanJournal of Medical Genetics 2002 Feb 15;108(1):75-77.
Ref ID: 222

2000

Finnell RH, Gelineau-van Waes J, Bennett GD, Barber RC, Wlodarczyk B, Shaw GM, Lammer EJ, Piedrahita JA, Eberwine JH. Genetic basis of susceptibility to environmentally induced neural tube defects. Annals of New York Academy of Science 2000; 919:261-277

1999

Shaw GM, Todoroff K, Finnell RH, Lammer EJ, Rozen R. Infant methionine synthase variants and risk for spina bifida. Journal of Medical Genetics 1999; 36:86-87

1998

Shaw GM, Rozen R, Finnell RH, Wasserman CR, Lammer EJ. Maternal vitamin use, genetic variation of infant methylenetetrahydrofolate reductase, and risk for spina bifida. American Journal of Epidemiology 1998; 148(1):30-37

Barber RC, Shaw GM, Lammer EJ, Greer KA, Lacey SW, Wasserman CR, Finnell RH. Lack of association between mutations in the folate receptora gene and spina bifida. American Journal of Genetics 1998; 76:310-317

1996

Shaw GM, Wasserman CR, Lammer EJ, O'Malley CD, Murray JC, Basart AM, Tolarova MM. Orofacial clefts, parental cigarette smoking, and transforming growth factor-alpha gene variants. American Journal of Medical Genetics 1996; 58 (3):551-561

Downloadable Study Summary:

PDF file Smoking and Oral Clefts