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gastroschisis: drug use

painkillersGastroschisis is believed to arise from interrupted blood supply to the developing abdominal wall, so factors influencing blood flow and oxygen stress are an important focus for our investigation. Our findings follow.

OVER-THE-COUNTER MEDICATIONS ELEVATE RISK

bullet Mothers taking aspirin or ibuprofen had a 4-5 time higher risk. These medications are strong cyclooxygenase inhibitors, active in pathways that decrease blood flow. Acetaminophen (which works by a different mechanism) showed no association with gastroschisis.
bullet Decongestants, particularly pseudoephedrine and phenylpropanolamine, more than doubled the risk. (Both are blood vessel constrictors.)
bullet The extra risk found with various medications was not due to the mother's reasons for taking them. Neither illness nor fever was associated with gastroschisis. reference information PDF file

SOLVENTS AND DYES USED IN HOBBIES MAY PLAY A ROLE

bullet Mothers were asked about work activities as well as hobbies during pregnancy. An industrial hygienist evaluated exposures that might be associated with each occupation/hobby.
bullet Several hobbiesranging from automechanics to weavingincreased risk for gastroschisis. All but 2 involved the use of solvents or colorants (dyes). reference information PDF file


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SUBSTANCE ABUSE RAISES RISK

bullet Using recreational drugs before or early in pregnancy increased the risk for gastroschisis. A higher risk was seen if the mother used more than one type of drug, and if both parents were drug users.
bullet Cocaine-using mothers were more than 4 times as likely to have a baby with gastroschisis.
bullet Using marijuana, amphetamines, or alcohol (either daily or binge drinking) increased risk by 2-4 times. reference information PDF file

RELATED TOPICS
bullet Medications
bullet Drugs
bullet Alcohol
bullet Solvents and Chemicals


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