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expanded AFP screening
neural tube defects
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anencephaly

Anencephaly—a type of neural tube defect—is a fatal birth defect where the brain and skull do not form completely. About 36% of pregnancies with anencephaly are stillborn. In California, the defect is seen in about 1 in 3,880 births (including medically indicated pregnancy terminations).

Nearly 100% of cases can be detected during pregnancy with either the expanded AFP screening (a prenatal blood test) or ultrasound.

The neural tube—the precursor to the brain and spinal cord—normally forms about 2-3 weeks after conception, often before a woman misses her period and realizes she might be pregnant. For this reason, we look for risk factors in the "periconception" period, including the month before the pregnancy began.



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Neural tube defects
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